Atypical clinical picture of waldenström’s macroglobulinemia: a difficult path to diagnosis

Macroglobulinemia; clinical features and differential diagnosis.

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Neem leaf extract (NLE) has medicinal properties, which have been attributed to its limonoid content. We identified the NLE tetranorterpenoid, nimbolide, as being the key limonoid responsible for the cytotoxicity of NLE in various preclinical models of human B-lymphocyte cancer. Of the models tested, Waldenströms macroglobulinemia (WM) cells were most sensitive to nimbolide, undergoing signific...

The difficult clinical diagnosis of erythropoietic protoporphyria.

We give a short survey of the Swedish erythropoietic protoporphyria patients (EPP) with respect to the lapsed time between symptom debut and diagnosis. With two examples we illustrate the consequence of undiagnosed EPP for the patient and also the family. We recall efforts to spread information among health workers in order to investigate patients suffering from extreme sun-exposure intolerance...

Diagnostic Tools of Waldenströms Macroglobulinemia - Best Possibilities for Non-invasive and Long-term Disease Monitoring.

Waldenströms macroglobulinemia (WM) is a B-cell malignancy characterized by high level of monoclonal immunoglobulin M (IgM) paraprotein in blood serum and associated with the bone marrow infiltration by malignant cells with lymphoplasmacytic differentiation. WM remains incurable advances in therapy. Most of WM cases are associated with a somatic point mutation L265P in MYD88. Significantly high...

15 Lymphedema : Clinical Picture , Diagnosis and Management

Lymphedema is swelling due to excess accumulation of lymph in the tissues caused by inadequate lymph drainage (Mortimer, 2010). The protein-rich lymph accumulates in tissue when reabsorption is hindered or when the lymphatics are absent or blocked (Gaber, 2009). Lymphedema is most commonly seen on lower limbs (Figure 1), rarely on the upper limbs, and extremely rarely on the head or the trunk. ...